Visible, irritating bites are due to an immune response from the binding of IgG and IgE antibodies to antigens in the mosquito's saliva. Some of the sensitizing antigens are common to all mosquito species, whereas others are specific to certain species. There are both immediate hypersensitivity reactions (Types I & III) and delayed hypersensitivity reactions (Type IV) to mosquito bites (see Clements, 2000).
There are several commercially available anti-itch medications, including those taken orally, such as Benadryl, or topically applied antihistamines and, for more severe cases, corticosteroids such as hydrocortisone and triamcinolone. Many ineffective home remedies exist, including calamine lotion. A paste of meat tenderizer containing papain and water breaks down the proteins in the mosquito saliva. Both using a brush to scratch the area surrounding the bite and running hot water (around 49 °C) over it can alleviate itching for several hours by reducing histamine-induced skin blood flow.[38] On the other hand, excessive scratching can irritate the bite and break the skin, leading to prolonged recovery and the possibility of infection or scarring.
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